Thursday, June 2, 2011

Kidney Disease

Intrarenal Arteries and Renal Segments

  • Ureter
  • Fibromuscular tube with mucosa
  • Upper: renal pelvis to upper border of sacrum
  • Middle: overlies sacrum
  • Lower: border of sacrum to bladder
  • Blood supply: upper from renal arteries, middle from ovarian or testicular arteries, lower from vesical arteries
  • Innervation of Kidneys and Ureters
    • Parasympathetic
      • Preganglionic: vagal fibers run through celiac and superior mesenteric plexuses, joining renal nerve plexus for distribution to ganglion cells in renal parenchyma, pelvis, and ureter
    • Sympathetic
      • Preganglionic: fibers run through splanchnic nerves (especially least), celiac, and superior mesenteric plexuses to synapse in aorticorenal ganglia
      • Postganglionic: fibers distributed to smooth muscle of renal vessels and gomeruli
    • Sensory: segmental visceral afferent fibers run parallel to sympathetic fibers to dorsal root ganglia and spinal segments T11-L2
     Renal cell carcinoma (hypernephroma): metastasized to lung (most common) or colon
  • Greatest risk factor: smoking
  • Nephroblastoma (Wilms’ tumor):
  • Rare renal malignant tumor of early childhood: 8/million incidence
  • Tumor cells produce renin, leading to hypertension 
  • Associated with hypospadias, cryptorchidism, ocular malformations 
  • Most common secondary renal tumor: breast metastasis

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