critical mediator of DIC is the release of a transmembrane glycoprotein called tissue factor (TF). TF is present on the surface of many cell types (including endothelial cells, macrophages, and monocytes) and is not normally in contact with the general circulation, but is exposed to the circulation after vascular damage. For example, TF is released in response to exposure to cytokines (particularly interleukin 1,tumor necrosis factor, and endotoxin[5]. This plays a major role in the development of DIC in septic conditions.
(referrent http://en.wikipedia.org/wiki/Disseminated_intravascular_coagulation#Pathophysiology)
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